无症状肝硬化患者发生消化性溃疡疾病的 predisposing 因素。（注：这里“predisposing”原词有误，可能是“predisposing”，意为“使易患；使倾向于” ，结合语境可翻译为“相关因素” ，整句译文为“无症状肝硬化患者发生消化性溃疡疾病的相关因素。” ）

Factors predisposing to peptic ulcer disease in asymptomatic cirrhotic patients.

作者信息

Kamalaporn P, Sobhonslidsuk A, Jatchavala J, Atisook K, Rattanasiri S, Pramoolsinsap C

机构信息

Department of Medicine, Ramathibodi Hospital, Bangkok, Thailand.

出版信息

Aliment Pharmacol Ther. 2005 Jun 15;21(12):1459-65. doi: 10.1111/j.1365-2036.2005.02507.x.

DOI:10.1111/j.1365-2036.2005.02507.x

PMID:15948813

Abstract

BACKGROUND

There is a high prevalence of peptic ulcer in cirrhotic patients, but the pathogenesis of peptic ulcer in cirrhosis remains inconclusive.

AIM

To investigate factors associated with peptic ulcer and to evaluate peptic ulcer prevalence in asymptomatic cirrhotic patients.

METHODS

A total of 130 cirrhotics were recruited into the study for endoscopic screening. Data were collected and biochemical tests were done. Doppler ultrasound was used to assess the portal vein velocity and size. Patients underwent endoscopy for the presence of varices and peptic ulcer. Helicobacter pylori infection was confirmed by urease test, histology and 14C-urea breath test. Statistical analysis was performed.

RESULTS

Peptic ulcer was detected in 50 (39%) cases. Between peptic ulcer and non-peptic ulcer groups, there were no significant differences in age, sex, alcoholic drinking, smoking, non-steroidal anti-inflammatory drug use, portal vein velocity and size, except for H. pylori infection (P = 0.006), serum albumin (P = 0.02) and Child-Pugh score (P = 0.03). By multivariate analysis, H. pylori infection (OR: 3.26; 95% CI: 1.49-7.13; P = 0.003), Child-Pugh classes B (OR: 2.48; 95% CI: 1.04-5.91; P = 0.04) and C (OR: 3.26; 95% CI: 1.2-8.81; P = 0.02) were independently associated with peptic ulcer.

CONCLUSION

H. pylori infection and advanced cirrhosis are important factors associated with active peptic ulcer.

摘要

背景

肝硬化患者中消化性溃疡的患病率很高，但肝硬化患者消化性溃疡的发病机制仍无定论。

目的

研究与消化性溃疡相关的因素，并评估无症状肝硬化患者中消化性溃疡的患病率。

方法

共招募130例肝硬化患者纳入本研究进行内镜筛查。收集数据并进行生化检测。使用多普勒超声评估门静脉速度和大小。患者接受内镜检查以确定是否存在静脉曲张和消化性溃疡。通过尿素酶试验、组织学和14C-尿素呼气试验确认幽门螺杆菌感染。进行统计学分析。

结果

50例（39%）患者检测到消化性溃疡。消化性溃疡组和非消化性溃疡组之间，除幽门螺杆菌感染（P = 0.006）、血清白蛋白（P = 0.02）和Child-Pugh评分（P = 0.03）外，年龄、性别、饮酒、吸烟、非甾体抗炎药使用、门静脉速度和大小均无显著差异。多因素分析显示，幽门螺杆菌感染（OR：3.26；95%CI：1.49 - 7.13；P = 0.003）、Child-Pugh B级（OR：2.48；95%CI：1.04 - 5.91；P = 0.04）和C级（OR：3.26；95%CI：1.2 - 8.81；P = 0.02）与消化性溃疡独立相关。