英国临床数据库在加强儿科药物研究方面的潜力。
The potential of UK clinical databases in enhancing paediatric medication research.
作者信息
Wong Ian C K, Murray Macey L
机构信息
Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, London, UK.
出版信息
Br J Clin Pharmacol. 2005 Jun;59(6):750-5. doi: 10.1111/j.1365-2125.2005.02450.x.
Abstract
The research potential of many UK clinical databases is not being realized. A recent report published by the Royal College of Paediatrics & Child Health stated that there is a need to build research capacity and support in the area of paediatric pharmacology, with specific emphasis on the use of clinical databases. This article presents the databases available in the UK for medication research and gives some examples of paediatric studies conducted. The databases discussed include the Prescription Pricing Authority database, the General Practice Research Database, IMS Health databases (Medical Data Index, MIDAS Prescribing Insights, Disease-Analyser-Mediplus) and the Yellow Card Scheme. Other databases such as the Medicines Monitoring Unit (MEMO) and the Scottish Primary Care Computer System also have research potential in paediatric pharmacoepidemiology, but their population sizes are relatively small.
摘要
许多英国临床数据库的研究潜力尚未得到发挥。皇家儿科学与儿童健康学院最近发布的一份报告指出，有必要在儿科药理学领域建立研究能力并提供支持，特别强调临床数据库的使用。本文介绍了英国可用于药物研究的数据库，并给出了一些已开展的儿科研究实例。所讨论的数据库包括处方定价管理局数据库、全科医疗研究数据库、艾美仕市场研究公司的数据库（医学数据索引、MIDAS处方洞察、疾病分析器 - 医药加）以及黄卡计划。其他数据库，如药品监测单位（MEMO）和苏格兰初级医疗计算机系统，在儿科药物流行病学方面也具有研究潜力，但它们的样本量相对较小。
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