Raisin J, Hess B, Blatter M, Zimmermann A, Descoeudres C, Horber F F, Jaeger P
Medizinische Universitätspoliklinik, Inselspital, Bern.
Schweiz Med Wochenschr. 1992 Jan 8;122(1-2):11-3.
Reports mainly from Japan, recommend germanium (Ge)-containing compounds as "anti-cancer" and "immunostimulatory" remedies. We report on a 25-tear-old woman with stage II HIV disease who consumed a total of 47 g Ge as Ge-lactate-citrate 18%. She developed severe renal insufficiency (creatinine clearance 7 ml/min/1.73 m2, proteinuria 0.28 g/d) and hepatomegaly. Biopsies revealed tubulointerstitial nephropathy with vacuolar degeneration, mainly of distal tubular epithelia, and severe liver steatosis. Tissue Ge content in kidney and liver biopsy specimens was increased 68-and 140 fold respectively. In agreement with previous reports, renal dysfunction persisted 9 months later (creatinine clearance 11 ml/min/1.73 m2).
主要来自日本的报告推荐含锗（Ge）化合物作为“抗癌”和“免疫刺激”药物。我们报告了一名25岁患有II期HIV疾病的女性，她总共摄入了47克作为18%乳酸柠檬酸锗的锗。她出现了严重的肾功能不全（肌酐清除率7毫升/分钟/1.73平方米，蛋白尿0.28克/天）和肝肿大。活检显示为肾小管间质性肾病伴空泡变性，主要累及远端肾小管上皮，以及严重的肝脏脂肪变性。肾脏和肝脏活检标本中的组织锗含量分别增加了68倍和140倍。与之前的报告一致，9个月后肾功能障碍仍然存在（肌酐清除率11毫升/分钟/1.73平方米）。
