Van der Spoel J I, Stricker B H, Schipper M E, de Bruijn W, de Smet P A, Esseveld M R
Afd. Interne Geneeskunde, Onze Lieve Vrouwe Gasthuis, Amsterdam.
Ned Tijdschr Geneeskd. 1991 Jun 22;135(25):1134-7.
The case history is described of a woman aged 57 years with renal, hepatic and muscular damage attributed to intake of germanium lactate-citrate (a cumulative dose of 32.1 g germanium) over at least one year, as alternative treatment of metastatic breast cancer. Histological examination of biopsies showed highly vacuolated cytoplasm of the epithelial cells of the distal renal tubules and micro- and macrovesicular steatosis of centrilobular hepatocytes. After discontinuation of the germanium, serum aminotransferases and creatine kinase values returned to normal, but moderately severe renal impairment persisted.
报告了一名57岁女性的病例史，她因摄入乳酸 - 柠檬酸锗（锗累积剂量为32.1克）至少一年作为转移性乳腺癌的替代治疗，导致肾脏、肝脏和肌肉损伤。活检组织学检查显示远端肾小管上皮细胞的细胞质高度空泡化，以及小叶中心肝细胞的微泡和大泡性脂肪变性。停用锗后，血清氨基转移酶和肌酸激酶值恢复正常，但中度严重的肾功能损害仍然存在。
