一例由退伍军人诺卡菌引起的足菌肿成功治疗病例。

A successfully treated case of mycetoma due to Nocardia veterana.

作者信息

Kashima M, Kano R, Mikami Y, Takahama H, Ito M, Hasegawa A, Mizoguchi M

机构信息

Department of Dermatology, St Marianna University, Kawasaki, Kanagawa 216-8511, Japan.

出版信息

Br J Dermatol. 2005 Jun;152(6):1349-52. doi: 10.1111/j.1365-2133.2005.06551.x.

DOI:10.1111/j.1365-2133.2005.06551.x

PMID:15949008

Abstract

We report a successfully treated case of mycetoma from which an unusual Nocardia species was isolated. The isolate was identified as N. veterana by biochemical characterization and 16S ribosomal RNA gene sequencing, and it has not been previously reported as a causative agent of human mycetomas. Treatment with various antibiotics over 6 years and surgical resection failed to cure the disease. However, the combination of intravenous imipenem/cilastatin and amikacin along with oral clarithromycin and minocycline proved very effective in this case. This is the first case report of mycetoma due to N. veterana in a clinical setting.

摘要

我们报告了一例成功治愈的足菌肿病例，从中分离出一种罕见的诺卡菌属菌种。通过生化特性鉴定和16S核糖体RNA基因测序，该分离株被鉴定为旧称兽诺卡菌，此前尚未有作为人类足菌肿病原体的报道。6年来使用多种抗生素治疗及手术切除均未能治愈该疾病。然而，静脉注射亚胺培南/西司他丁和阿米卡星联合口服克拉霉素和米诺环素在该病例中被证明非常有效。这是临床环境中首例由旧称兽诺卡菌引起的足菌肿病例报告。