Radcliffe C, Peaper D, Grant M
Yale School of Medicine, New Haven, CT, USA.
Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
New Microbes New Infect. 2020 Dec 5;39:100833. doi: 10.1016/j.nmni.2020.100833. eCollection 2021 Jan.
Members of the genus are filamentous, Gram-positive, aerobic bacteria and exist ubiquitously in most environments. In 2001, the species was first isolated, and it predominantly causes pulmonary infections in immunocompromised hosts. We present the first report of a soft-tissue abscess caused by in a 59-year-old woman being treated for chronic cutaneous graft-versus-host disease. After failing to improve with empirical treatment, two incision and drainage procedures were required. She subsequently completed a 1-year course of oral antibiotic therapy consisting of trimethoprim-sulfamethoxazole then azithromycin. No relapse occurred over the next 5 years of follow up. To better characterize infections, we performed a systematic literature review and summarized all previously reported cases. Overall, the rising prevalence of immunocompromising conditions warrants increased vigilance for infections caused by atypical or opportunistic pathogens.
该属成员为丝状、革兰氏阳性需氧菌，广泛存在于大多数环境中。2001年，首次分离出该种，它主要在免疫功能低下的宿主中引起肺部感染。我们报告首例由该菌引起的软组织脓肿，患者为一名59岁女性，正在接受慢性皮肤移植物抗宿主病治疗。经验性治疗无效后，进行了两次切开引流手术。随后她完成了为期1年的口服抗生素治疗，先是服用甲氧苄啶-磺胺甲恶唑，然后是阿奇霉素。在接下来的5年随访中未复发。为了更好地描述该菌感染的特征，我们进行了系统的文献综述，并总结了所有先前报道的病例。总体而言，免疫功能低下情况的患病率上升，需要提高对非典型或机会性病原体引起感染的警惕性。
