Bergersen Bente M, Tonstad Serena, Sandvik Leiv, Bruun Johan N
Department of Infectious Diseases, Ullevål University Hospital, 0407 Oslo, Norway.
Int J STD AIDS. 2005 May;16(5):365-9. doi: 10.1258/0956462053888808.
Our objective was to compare the prevalence of high-density lipoprotein-cholesterol (HDL-c) level < 1 mmol/L in non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI) recipients in an unselected HIV-positive population. All HIV-positive patients living in Oslo who attended our outpatient clinic from April 1, 2000 to April 1, 2001 were invited to a study of cardiovascular risk factors. In this substudy, 40 NNRTI recipients and 124 PI recipients were included. Prevalence of HDL-c <1 mmol/L was 7.5% in the NNRTI recipients compared with 35.5% in the PI recipients (P <0.001). In the multivariate analyses, use of NNRTI was a significant protective factor (odds ratio [OR] 0.17; 95% confidence interval [CI] 0.05-0.66; P = 0.01) and elevated triglycerides a significant risk factor (OR 3.40; 95% CI 1.47-7.86; P = 0.004) for low HDL-c level. Our study shows that NNRTI recipients have a more favourable HDL-c profile than PI recipients, even when possible confounding factors are taken into account.
我们的目标是比较在未经过挑选的HIV阳性人群中，非核苷类逆转录酶抑制剂（NNRTI）和蛋白酶抑制剂（PI）接受者中高密度脂蛋白胆固醇（HDL-c）水平<1 mmol/L的患病率。所有于2000年4月1日至2001年4月1日期间在奥斯陆居住且到我们门诊就诊的HIV阳性患者均被邀请参加一项心血管危险因素研究。在这项子研究中，纳入了40名NNRTI接受者和124名PI接受者。NNRTI接受者中HDL-c<1 mmol/L的患病率为7.5%，而PI接受者中这一患病率为35.5%（P<0.001）。在多变量分析中，使用NNRTI是HDL-c水平低的一个显著保护因素（比值比[OR] 0.17；95%置信区间[CI] 0.05 - 0.66；P = 0.01），而甘油三酯升高是一个显著危险因素（OR 3.40；95% CI 1.47 - 7.86；P = 0.004）。我们的研究表明，即使考虑到可能的混杂因素，NNRTI接受者的HDL-c情况也比PI接受者更有利。
