Demirbag S, Tander B, Atabek C, Surer I, Oztürk H, Cetinkursun S
Department of Pediatric Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
Ann Trop Paediatr. 2005 Jun;25(2):135-7. doi: 10.1179/146532805X45737.
BACKGROUND/AIM: Although topical glyceryl trinitrate ointment (GTN) has become a popular treatment for anal fissure in adults, its use in children is still limited. We aimed to determine the effectiveness and safety of topical GTN in the long-term management of anal fissure in children, which has not yet been reported.
Thirty-one children with anal fissure who received topical 0.2% GTN treatment between 1997 and 1998 were evaluated in 2004.
Ten patients had one or more relapses after initial treatment with 0.2% GTN, all within 1 year of first onset of anal fissure. No further recurrences were diagnosed during the 4-year follow-up period.
Although early recurrence can occur, topical GTN ointment is effective in healing chronic anal fissures in children.
背景/目的：尽管局部应用硝酸甘油软膏（GTN）已成为成人肛裂的常用治疗方法，但其在儿童中的应用仍然有限。我们旨在确定局部应用GTN对儿童肛裂长期治疗的有效性和安全性，目前尚无相关报道。
对1997年至1998年间接受局部0.2% GTN治疗的31例肛裂患儿于2004年进行评估。
10例患者在初次使用0.2% GTN治疗后出现一次或多次复发，均在肛裂首次发作的1年内。在4年的随访期内未诊断出进一步复发。
尽管可能会早期复发，但局部应用GTN软膏对治愈儿童慢性肛裂有效。
