Sen Orhan, Gokcel Adnan, Kizilkilic Osman, Erdogan Bulent, Aydin M Volkan, Sezgin Nurzen, Yalcin Ozlem, Caner Hakan, Altinors Nur
Department of Neurosurgery, Faculty of Medicine, Baskent University, Adana, Turkey.
Neurol Res. 2005 Jun;27(4):452-5. doi: 10.1179/016164105X15631.
Epidural fibrosis (EF) is a part of the normal physiological tissue response to laminectomy and it is an important cause of failed back surgery syndrome (FBSS). Osteoprotegerin (OPG) is a soluble member of the tumor necrosis factor receptor family, and is expressed in high concentrations by a variety of tissues and cell types. The objective of this study was to evaluate the relationship between serum OPG levels, and the existence of postoperative EF in patients with lumbar disc herniation. It has been suggested that cytokines and growth factors, which play a role in the wound healing, may enhance the expression of OPG.
Forty women who underwent surgery for lumbar disc herniation were included in this study. Postoperative MRI was performed to assess EF in all patients.
The serum OPG levels of subjects with postoperative EF were significantly higher than those of subjects without postoperative EF (4.72 +/- 0.27 versus 3.25 +/-0.41 pmol/l; p=0.005)
Although the role of OPG in the development of EF is poorly understood, our results suggest that elevated levels of serum OPG are associated with and may play a role in the pathogenesis of fibrotic process.
硬膜外纤维化（EF）是椎板切除术后正常生理组织反应的一部分，也是腰椎手术失败综合征（FBSS）的重要原因。骨保护素（OPG）是肿瘤坏死因子受体家族的可溶性成员，在多种组织和细胞类型中高表达。本研究的目的是评估血清OPG水平与腰椎间盘突出症患者术后EF存在之间的关系。有人提出，在伤口愈合中起作用的细胞因子和生长因子可能会增强OPG的表达。
本研究纳入了40例行腰椎间盘突出症手术的女性患者。对所有患者进行术后MRI检查以评估EF。
术后出现EF的受试者血清OPG水平显著高于未出现术后EF的受试者（4.72±0.27对3.25±0.41 pmol/l；p = 0.005）
尽管OPG在EF发生中的作用尚不清楚，但我们的结果表明，血清OPG水平升高与纤维化过程的发病机制相关且可能在其中起作用。
