Soliman Sara, Ahmed Mamdouh
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Open Access Maced J Med Sci. 2016 Dec 15;4(4):705-708. doi: 10.3889/oamjms.2016.123. Epub 2016 Nov 22.
Osteoprotegerin (OPG) is considered to be the cytokine that plays an important role in the healing process. OPG regulates bone cell biology, osteoblast-osteoclast, bone-immune cross-talk and maintenance of bone mass. It plays an important role in the development, induction, and repair of bone. Orthognathic surgery as multiples segmental osteotomies has been taken as a model surgery to assess the changes in osteoprotegerin levels in the post-operative bone healing period.
The aim of the study was to evaluate OPG as immunological caliper of bone healing.
OPG was evaluated in nine patients seeking orthognathic surgery. Patients were examined and checked to be medically and immunologically free prior to surgery. Blood samples were collected immediate pre-operative as control group and for six weeks post-operative as study group.
Data were collected from nine consecutive patients. The results showed higher levels of OPG. it showed significant increase in the immediate post-operative value (p = 0.001) which started to increase gradually during the six weeks (p < 0.001).
Significant higher levels of OPG during the healing period of orthognathic surgery suggest the its use as immunological caliper of bone healing.
骨保护素（OPG）被认为是在愈合过程中起重要作用的细胞因子。OPG调节骨细胞生物学、成骨细胞-破骨细胞、骨-免疫相互作用以及骨量维持。它在骨的发育、诱导和修复中起重要作用。正颌外科手术作为多节段截骨术，已被用作评估术后骨愈合期骨保护素水平变化的模型手术。
本研究的目的是评估OPG作为骨愈合的免疫卡尺。
对9例寻求正颌外科手术的患者进行OPG评估。术前对患者进行检查，确保其在医学和免疫学上无异常。术前即刻采集血样作为对照组，术后六周采集血样作为研究组。
收集了9例连续患者的数据。结果显示OPG水平较高。术后即刻值显著升高（p = 0.001），并在六周内逐渐升高（p < 0.001）。
正颌外科手术愈合期OPG水平显著升高，提示其可作为骨愈合的免疫卡尺。
