Chen Shi-Yao, Liu Tian-Shu, Fan Xiao-Ming, Dong Ling, Fang Guo-Ting, Tu Chuan-Tao, Gu Xiu-Ying, Wang Ji-Yao
Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhonghua Yi Xue Za Zhi. 2005 Mar 30;85(12):802-6.
To explore the Helicobacter pylori (Hp) infection status in Shanghai and its risk factors.
A questionnaire survey including 60 items related to Hp was conducted among 1925 persons, 976 males (50.7%) and 949 females (49.3%), aged 37 +/- 11 (15 approximately 72), selected by cluster sampling in 12 rural and urban areas in Shanghai. Peripheral blood was collected to detect Hp IgG antibody so as to evaluate the past infection status and (14)C urea breath test (UBT) was performed so as to evaluate the present infection status. Fecal Hp antigen test was done in the subjects under 18 years of age.
1822 of the 1925 subjects (94.6%) underwent the 3 tests. were followed antibody detection and (14)C UBT and response with questionnaires. The Hp infection rate was 66.4% in general, and 68.4% in the females, somehow higher than in the males (64.3%, P = 0.067). The infection rate was different in different age groups, was the lowest in the age group of 15 approximately 19 (44.4%) and the highest 70% in age group of 20 approximately 30 (70%), then somewhat lower and gradually became higher. Socio-economic status was related to Hp infection. Hp infection was related with such factors as eating raw vegetables and fruits, and never washing raw vegetables and fruits before eating. The knowledge rate about Hp infection was only 33.2% among the respondents. Only 23.8% of the respondents knew well the transmission route of Hp.
Hp infection rate is rather high in Shanghai. Hp infection is related to socio-economic status, and family dietary and sanitary habits.
探讨上海地区幽门螺杆菌（Hp）感染状况及其危险因素。
采用整群抽样方法，在上海12个城乡地区选取1925人进行问卷调查，其中男性976名（50.7%），女性949名（49.3%），年龄37±11岁（15至72岁）。问卷包含60项与Hp相关内容。采集外周血检测Hp IgG抗体以评估既往感染状况，同时进行碳-14尿素呼气试验（UBT）以评估现感染状况。对18岁以下受试者进行粪便Hp抗原检测。
1925名受试者中1822名（94.6%）接受了上述三项检测，并进行了抗体检测、碳-14 UBT及问卷调查。总体Hp感染率为66.4%，女性感染率为68.4%，略高于男性（64.3%，P = 0.067）。不同年龄组感染率不同，15至19岁年龄组最低（44.4%），20至30岁年龄组最高（70%），之后有所下降并逐渐上升。社会经济状况与Hp感染有关。Hp感染与食用生蔬菜和水果、进食前从不清洗生蔬菜和水果等因素有关。受访者中对Hp感染的知晓率仅为33.2%。仅23.8%的受访者清楚Hp的传播途径。
上海地区Hp感染率较高。Hp感染与社会经济状况、家庭饮食及卫生习惯有关。
