需要修复的染色质：H2AX的磷酸化将染色质与DNA修复联系起来。
Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair.
作者信息
Thiriet Christophe, Hayes Jeffrey J
机构信息
Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York 14642, USA.
出版信息
Mol Cell. 2005 Jun 10;18(6):617-22. doi: 10.1016/j.molcel.2005.05.008.
PMID:15949437
Abstract
A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair.
摘要
最近的一系列报告已经牢固地确立了一种与DNA双链断裂相关的组蛋白翻译后修饰和染色质修饰活性募集之间的机制联系。这些论文表明，除了为转录调控提供信号外，特定的组蛋白“密码”还可以协调和靶向参与DNA修复的多种活性。
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