组蛋白翻译后修饰与对DNA双链断裂的反应。
Histone post-translational modifications and the response to DNA double-strand breaks.
作者信息
Wurtele Hugo, Verreault Alain
机构信息
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Pavillon Marcelle-Coutu, 2950 Chemin Polytechnique, Montreal H3T 1J4, Canada.
出版信息
Curr Opin Cell Biol. 2006 Apr;18(2):137-44. doi: 10.1016/j.ceb.2006.02.008. Epub 2006 Feb 17.
The packaging of DNA into chromatin creates a number of significant barriers to the detection of DNA lesions and their timely and accurate repair. Eukaryotic cells have evolved a number of enzymes that modulate chromatin structure and facilitate DNA repair. Recent research illustrates how nucleosome remodelling enzymes cooperate with both DNA-damage-inducible and constitutive histone modifications to promote many facets of the cellular response to DNA damage.
将DNA包装成染色质会对DNA损伤的检测及其及时、准确修复造成诸多重大障碍。真核细胞已经进化出多种可调节染色质结构并促进DNA修复的酶。最近的研究阐明了核小体重塑酶如何与DNA损伤诱导型和组成型组蛋白修饰协同作用，以促进细胞对DNA损伤反应的多个方面。
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