Cohen Kadosh Roi, Henik Avishai, Rubinsten Orly, Mohr Harald, Dori Halit, van de Ven Vincent, Zorzi Marco, Hendler Talma, Goebel Rainer, Linden David E J
Department of Behavioral Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Neuropsychologia. 2005;43(9):1238-48. doi: 10.1016/j.neuropsychologia.2004.12.017. Epub 2005 Feb 26.
Many studies have suggested that the intraparietal sulcus (IPS), particularly in the dominant hemisphere, is crucially involved in numerical comparisons. However, this parietal structure has been found to be involved in other tasks that require spatial processing or visuospatial attention as well. fMRI was used to investigate three different magnitude comparisons in an event-related-block design: (a) Which digit is larger in numerical value (e.g., 2 or 5)? (b) Which digit is brighter (e.g., 3 or 3)? (c) Which digit is physically larger (e.g., 3 or 3)? Results indicate a widespread cortical network including a bilateral activation of the intraparietal sulci for all different comparisons. However, by computing contrasts of brain activation between the respective comparison conditions and applying a cortical distance effect as an additional criterion, number-specific activation was revealed in left IPS and right temporal regions. These results indicate that there are both commonalities and differences in the spatial layout of the brain systems for numerical and physical comparisons and that especially the left IPS, while involved in magnitude comparison in general, plays a special role in number comparison.
许多研究表明，顶内沟（IPS），尤其是优势半球中的顶内沟，在数字比较中起着关键作用。然而，人们发现这个顶叶结构也参与其他需要空间处理或视觉空间注意力的任务。在一项事件相关块设计中，功能磁共振成像（fMRI）被用于研究三种不同的大小比较：（a）哪个数字数值更大（例如，2还是5）？（b）哪个数字更亮（例如，3还是3）？（c）哪个数字在物理上更大（例如，3还是3）？结果表明，包括顶内沟双侧激活在内的广泛皮层网络参与了所有不同的比较。然而，通过计算各比较条件之间的脑激活对比，并将皮层距离效应作为附加标准，在左侧顶内沟和右侧颞区发现了数字特异性激活。这些结果表明，在用于数字和物理比较的脑系统空间布局中既有共性也有差异，特别是左侧顶内沟，虽然总体上参与大小比较，但在数字比较中发挥着特殊作用。
