Zhao Allan Z
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Curr Top Dev Biol. 2005;67:207-24. doi: 10.1016/S0070-2153(05)67006-8.
The 3', 5'-cyclic adenosine monophosphate (cAMP) is a classic second messenger that is intimately involved in the regulation of food intake at the hypothalamus. cAMP can mediate the orexigenic and anorectic effects of various peripheral hormones or neuropeptides in a region-specific and neuron-specific manner. The importance of cAMP is particularly highlighted in a series of findings about cAMP transducing the anorectic signals of leptin and alpha-msh. This chapter provides an overview of several studies on how regulation of food intake takes place with cAMP as the second messenger in the hypothalamus.
3',5'-环磷酸腺苷（cAMP）是一种经典的第二信使，它在下丘脑对食物摄入的调节中起着密切作用。cAMP可以以区域特异性和神经元特异性的方式介导各种外周激素或神经肽的促食欲和抑食欲作用。cAMP在一系列关于其转导瘦素和α-促黑素的抑食欲信号的研究中，其重要性尤其凸显。本章概述了几项关于以下内容的研究：在下丘脑中以cAMP作为第二信使时，食物摄入是如何受到调节的。
