Williamson Donald A, Ravussin Eric, Wong Ma-Li, Wagner A, Dipaoli A, Caglayan Sinan, Ozata Metin, Martin Corby, Walden Heather, Arnett Cheryl, Licinio Julio
Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA 70808, USA.
Appetite. 2005 Aug;45(1):75-80. doi: 10.1016/j.appet.2005.01.002.
Leptin deficiency has been associated with extreme obesity and hyperphagia in rodents and humans. A rare genetic disorder in humans yields the absence of the hormone leptin, extreme obesity, and a ravenous appetite. Reports on these rare cases have indicated that therapy using leptin injections can yield significant weight loss and changes in appetite. The aim of this report on acute leptin therapy in three leptin deficient adults was to provide a microanalysis of changes in eating behavior and ratings of hunger and satiety. In addition to substantial weight loss, 15 weeks of leptin therapy was associated with approximately 50% reduction in food intake and substantial changes in ratings of hunger and satiety before most meals. After short-term leptin therapy, the three participants ate until ratings indicated they were satiated, which was comparable to the ratings before leptin therapy. These findings suggest that one of the primary effects of acute leptin therapy may be to reduce the ravenous hunger associated with leptin deficiency, resulting in reduced food intake and significant weight loss. These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity.
瘦素缺乏与啮齿动物和人类的极度肥胖及食欲过盛有关。人类中一种罕见的遗传疾病会导致缺乏激素瘦素、极度肥胖和食欲旺盛。关于这些罕见病例的报告表明，使用瘦素注射疗法可显著减轻体重并改变食欲。本报告针对三名瘦素缺乏的成年人进行急性瘦素治疗，目的是对饮食行为变化以及饥饿和饱腹感评分进行微观分析。除了大幅减重外，15周的瘦素治疗还使食物摄入量减少了约50%，并且在大多数餐前饥饿和饱腹感评分发生了显著变化。短期瘦素治疗后，三名参与者会一直吃到评分显示他们有饱腹感为止，这与瘦素治疗前的评分相当。这些发现表明，急性瘦素治疗的主要作用之一可能是减少与瘦素缺乏相关的强烈饥饿感，从而导致食物摄入量减少和显著减重。将结合有关瘦素及其对食欲和肥胖影响的科学文献来讨论这些结果。
