de Rivera C, Shukitt-Hale B, Joseph J A, Mendelson J R
Department of Speech-Language Pathology, University of Toronto, Toronto, Ont., Canada M5G 1V7.
Neurobiol Aging. 2006 Jul;27(7):1035-44. doi: 10.1016/j.neurobiolaging.2005.05.003. Epub 2005 Jun 13.
We investigated whether a 2-month dietary supplementation of antioxidants, in the form of blueberry phytochemicals, could reverse or retard the age-related decline in temporal processing speed observed in the aged rat. To this end, extracellular single unit responses to frequency modulated (FM) sweeps were recorded in the primary auditory cortex (AI) of aged rats that had been placed on either a blueberry-supplemented or control diet 2 months prior to the physiological recordings. Results showed that most cells recorded from the blueberry-fed rats responded most vigorously to fast FM sweeps, similar to that observed in young rats. In contrast, the majority of cells recorded from the control rats showed a preference for slow FM sweep rates. These results suggest that age-related changes in temporal processing speed in A1 may be reversed by dietary supplementation of blueberry phytochemicals.
我们研究了以蓝莓植物化学物质形式进行为期2个月的抗氧化剂膳食补充，是否能够逆转或延缓老年大鼠中观察到的与年龄相关的时间处理速度下降。为此，在生理记录前2个月接受蓝莓补充饮食或对照饮食的老年大鼠的初级听觉皮层（AI）中，记录了对调频（FM）扫描的细胞外单单位反应。结果显示，从喂食蓝莓的大鼠中记录的大多数细胞对快速FM扫描反应最为强烈，这与在年轻大鼠中观察到的情况相似。相比之下，从对照大鼠中记录的大多数细胞表现出对慢FM扫描速率的偏好。这些结果表明，通过膳食补充蓝莓植物化学物质，A1中与年龄相关的时间处理速度变化可能会被逆转。
