Tambour Sophie, Didone Vincent, Tirelli Ezio, Quertemont Etienne
Laboratoire de Neurosciences Comportementales et Psychopharmacologie, Université de Liège, Boulevard du Rectorat 5/B32, 4000 Liège, Belgium.
Eur Neuropsychopharmacol. 2005 Dec;15(6):655-62. doi: 10.1016/j.euroneuro.2005.04.014. Epub 2005 Jun 9.
Acetaldehyde, the first product of ethanol metabolism, has been suggested to play a major role in many behavioral effects of ethanol. However, very few studies have directly tested the behavioral effects of the acute administration of acetaldehyde. In particular, the role of this metabolite in ethanol-induced anxiolytic effects has never been extensively tested. The aim of the present study was to characterize the anxiolytic effects of acetaldehyde in two strains of mice, C57BL/6J and CD1 mice with the elevated plus-maze procedure. The results show that acute injections of ethanol (1-2 g/kg) induced significant dose-dependent anxiolytic effects in both strains of mice. In contrast, acetaldehyde failed to produce any anxiolytic effect, although it induced a significant hypolocomotor effect at the highest doses. In an independent experiment, cyanamide, an aldehyde dehydrogenase inhibitor, prevented the locomotor stimulant effects of ethanol, although it failed to alter its anxiolytic effects. Together, the results of the present study indicate that acetaldehyde is not involved in ethanol-induced anxiolytic effects, although it may be involved in its sedative/hypolocomotor effects.
乙醛是乙醇代谢的首个产物，有人认为它在乙醇的许多行为效应中起主要作用。然而，极少有研究直接测试急性给予乙醛的行为效应。特别是，这种代谢产物在乙醇诱导的抗焦虑效应中的作用从未得到广泛测试。本研究的目的是通过高架十字迷宫实验来表征乙醛在两种品系小鼠（C57BL/6J和CD1小鼠）中的抗焦虑效应。结果表明，急性注射乙醇（1 - 2克/千克）在两种品系小鼠中均诱导出显著的剂量依赖性抗焦虑效应。相比之下，乙醛未能产生任何抗焦虑效应，尽管在最高剂量时它诱导出显著的运动减少效应。在一项独立实验中，乙醛脱氢酶抑制剂氰酰胺可阻止乙醇的运动兴奋效应，尽管它未能改变乙醇的抗焦虑效应。总之，本研究结果表明，乙醛不参与乙醇诱导的抗焦虑效应，尽管它可能参与其镇静/运动减少效应。
