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Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation.

作者信息

Chung Hwa-Jin, Jung Ok-Jai, Chae Mi Jin, Hong Sung-Yu, Chung Kwang-Hoe, Lee Sang Kook, Ryu Chung-Kyu

机构信息

College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3380-4. doi: 10.1016/j.bmcl.2005.05.022.

DOI:10.1016/j.bmcl.2005.05.022
PMID:15950466
Abstract

A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs.

摘要

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