Vitale Alessandro, Hinz Giselbert
Istituto di Biologia e Biotecnologia Agraria, CNR, 20133 Milano, Italy.
Trends Plant Sci. 2005 Jul;10(7):316-23. doi: 10.1016/j.tplants.2005.05.001.
Vacuoles receive their proteins through the secretory pathway, this requires protein sorting signals and molecular machineries that, until recently, have been believed to be markedly distinct for lytic and storage vacuoles. However, new biochemical, morphological and genetic data indicate that the only known class of vacuolar sorting receptors, believed to be specific for lytic vacuoles, might also be involved in the sorting of certain storage proteins. Furthermore, storage vacuoles can have a complex multimembrane structure that is difficult to explain based on a single trafficking mechanism. A new array of possible molecular interactions is thus emerging that no longer supports a clear-cut distinction between the two types of vacuoles based on sorting signals and putative receptors.
液泡通过分泌途径接收蛋白质，这需要蛋白质分选信号和分子机制，直到最近，人们一直认为这些信号和机制对于溶酶体和储存液泡来说是明显不同的。然而，新的生化、形态学和遗传学数据表明，唯一已知的一类液泡分选受体，以前被认为是溶酶体特有的，可能也参与了某些储存蛋白的分选。此外，储存液泡可以具有复杂的多膜结构，仅基于单一的运输机制很难解释这一点。因此，一系列新的可能的分子相互作用正在出现，这些相互作用不再支持基于分选信号和假定受体对这两种类型的液泡进行明确区分。
