Supler M L, Mickle J P
Department of Neurosurgery, University of Florida, Gainesville 32610.
Surg Neurol. 1992 Jun;37(6):472-6. doi: 10.1016/0090-3019(92)90138-d.
Lymphocytic hypophysitis (LH) is a rare inflammatory disease of the pituitary that produces hypopituitarism. It more commonly affects women during pregnancy or shortly after childbirth. Of the 34 reported cases only three have been males. We report the fourth known case of lymphocytic hypophysitis in a male who presented with hypopituitarism, diplopia, and cavernous sinus involvement. To our knowledge this is the second report of involvement of the cavernous sinus by LH. A comparative study of all four male cases is also presented. The findings reveal that the mean age at presentation in the male patients is 52.3, nearly 21 years older than that reported for female cases. Impotence with associated decrease in libido is the most common presenting symptom. Extraocular muscle palsy with associated infiltration of the cavernous sinus is an exclusive finding among male patients with LH. Concerning prognosis, none of the male patients regained pituitary function that had been lost at the time of presentation but required chronic replacement therapy.
淋巴细胞性垂体炎（LH）是一种罕见的垂体炎症性疾病，可导致垂体功能减退。它更常见于孕期或产后不久的女性。在已报道的34例病例中，只有3例为男性。我们报告了第四例已知的男性淋巴细胞性垂体炎病例，该患者表现为垂体功能减退、复视和海绵窦受累。据我们所知，这是LH累及海绵窦的第二例报告。我们还对所有四例男性病例进行了对比研究。研究结果显示，男性患者的平均发病年龄为52.3岁，比女性病例报告的年龄大近21岁。伴有性欲减退的阳痿是最常见的首发症状。伴有海绵窦浸润的眼外肌麻痹是男性LH患者独有的表现。关于预后，所有男性患者均未恢复发病时丧失的垂体功能，而是需要长期替代治疗。
