Kaplan C
Laboratoire d'immunologie plaquettaire, INTS, 6, Paris, France.
Transfus Clin Biol. 2005 Jun;12(2):131-4. doi: 10.1016/j.tracli.2005.04.012.
The allo-immune thrombocytopenias are the major cause of severe thrombocytopenia in the fetus and the neonate. The frequency of this affection has been evaluated to be 1 out of 800 to 1000 live births. The deleterious consequences of severe thrombocytopenia are intracranial hemorrhages leading to death or neurological sequelae. Progress in platelet immunology and antenatal medicine has allowed a better diagnosis of this affection and development of the antenatal management of high-risk pregnancies. Nevertheless there are unsolved questions, particularly concerning the mechanism of the maternal immunization, the laboratory difficulties for the identification of the alloantibodies, the absence of antenatal management standardization.
同种免疫性血小板减少症是胎儿和新生儿严重血小板减少的主要原因。据评估，这种疾病在每800至1000例活产中的发病率为1例。严重血小板减少症的有害后果是颅内出血，可导致死亡或神经后遗症。血小板免疫学和产前医学的进展使得对这种疾病有了更好的诊断，并发展了高危妊娠的产前管理。然而，仍有一些未解决的问题，特别是关于母体免疫的机制、同种抗体鉴定的实验室困难以及产前管理缺乏标准化。
