van Balkom Bas W M, van Gestel Renske A, Brouwers Jos F H M, Krijgsveld Jeroen, Tielens Aloysius G M, Heck Albert J R, van Hellemond Jaap J
Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.
J Proteome Res. 2005 May-Jun;4(3):958-66. doi: 10.1021/pr050036w.
Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.
曼氏血吸虫是一种寄生于宿主血管中的寄生虫。我们通过一维SDS-PAGE和LC-MS/MS以及来自正在进行的基因组测序项目的EST数据库，绘制了曼氏血吸虫体表外表面结构蛋白质组图谱。我们鉴定出740种蛋白质，其中43种是体表特异性的。这些蛋白质中的许多与任何非血吸虫蛋白质都没有同源性，这表明血吸虫的外表面包含特定且独特的蛋白质，这些蛋白质可能对寄生虫的生存至关重要。
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