Neth O W, Bajaj-Elliott M, Turner M W, Klein N J
Infectious Diseases and Microbiology Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK.
Br J Haematol. 2005 Jun;129(6):713-22. doi: 10.1111/j.1365-2141.2005.05462.x.
Chemotherapy-induced neutropenia increases the risk of infection. There appears to be a wide variability in the severity and length of infective episodes. Susceptibility to infections is determined by the underlying malignant disease and its treatment, environmental factors (e.g. nutritional state of the patient and hygiene) and genetically determined variations of the immune system. The majority of primary immunodeficiencies are rare (c. frequency one in 10 000), whereas some genetic polymorphisms in the innate immune system, such as profound mannose-binding lectin deficiency, are much more common (c. frequency one in 10). Here, we review the potential role of the innate immune system in determining susceptibility to infections in patients with neutropenia.
化疗引起的中性粒细胞减少会增加感染风险。感染发作的严重程度和持续时间似乎存在很大差异。对感染的易感性取决于潜在的恶性疾病及其治疗、环境因素（如患者的营养状况和卫生情况）以及免疫系统的基因决定变异。大多数原发性免疫缺陷较为罕见（约为万分之一的发病率），而先天性免疫系统中的一些基因多态性，如严重的甘露糖结合凝集素缺乏症，则更为常见（约为十分之一的发病率）。在此，我们综述先天性免疫系统在确定中性粒细胞减少患者感染易感性方面的潜在作用。
