迪斯科！视锥蛋白的解离：对视锥细胞快速且嘈杂的生命历程的解释。

DISCO! Dissociation of cone opsins: the fast and noisy life of cones explained.

作者信息

Travis Gabriel H

机构信息

Department of Ophthalmology, UCLA School of Medicine, Los Angeles, CA 90095, USA.

出版信息

Neuron. 2005 Jun 16;46(6):840-2. doi: 10.1016/j.neuron.2005.06.003.

DOI:10.1016/j.neuron.2005.06.003

PMID:15953411

Abstract

Vertebrate retinas contain two types of photoreceptors. Rods are for vision in dim light, while cones provide high-speed color vision in bright light. In this issue of Neuron, Kefalov et al. present data to explain the reduced sensitivity and faster response kinetics of cones. They show that the chromophore dissociates from cone but not rod visual pigment, yielding apo-opsin. This apo-opsin activates the signaling cascade to desensitize cones and speed the photoresponse.

摘要

脊椎动物的视网膜包含两种光感受器。视杆细胞用于弱光下的视觉，而视锥细胞在强光下提供高速的彩色视觉。在本期《神经元》杂志中，凯法洛夫等人展示了相关数据，以解释视锥细胞敏感性降低和更快反应动力学的原因。他们发现，发色团从视锥细胞而非视杆细胞的视觉色素上解离，产生脱辅基视蛋白。这种脱辅基视蛋白激活信号级联反应，使视锥细胞脱敏并加快光反应。