Müntzing J, Kirdani R, Murphy G P, Sandberg A A
Invest Urol. 1977 May;14(6):492-5.
The zinc uptake in the dorsolateral prostate of rats was studied after different hormonal manipulations. Orchiectomy reduced the uptake of 65Zn. Administration of estradiol benzoate to orchiectomized rats doubled the 65Zn uptake, a phenomenon which was not observed in orchiectomized-adrenalectomized rats. Adrenalectomy in orchiectomized rats had no effect on the concentration of radioactivity beyond the castration-induced decrease. A prolactin release inhibitor, 6-methyl-8-erogelenylacetamide, reduced the radioactivity concentration without changing the weight of the gland. Cyproterone acetate reduced the weight but not the radioactivity concentration. The concentration of 65Zn in the ventral prostate was not changed by orchiectomy, adrenalectomy, or the administration of estradiol benzoate, prolactin release inhibiors, or cyproterone acetate. The results suggest an important role for prolactin in the zinc uptake in the dorsolateral prostate but not in the ventral prostate.
在进行不同的激素处理后，研究了大鼠背外侧前列腺对锌的摄取情况。去势降低了65Zn的摄取。给去势大鼠注射苯甲酸雌二醇使65Zn摄取量增加了一倍，而去势-肾上腺切除大鼠未观察到这种现象。去势大鼠进行肾上腺切除后，除了阉割引起的放射性浓度降低外，对其没有影响。一种催乳素释放抑制剂，6-甲基-8-麦角酰乙酰胺，降低了放射性浓度，但未改变腺体重量。醋酸环丙孕酮降低了腺体重量，但未改变放射性浓度。去势、肾上腺切除、注射苯甲酸雌二醇、催乳素释放抑制剂或醋酸环丙孕酮均未改变腹侧前列腺中65Zn的浓度。结果表明，催乳素在背外侧前列腺对锌的摄取中起重要作用，而在腹侧前列腺中则不然。
