南非的十二指肠溃疡：自制玉米粉与研磨玉米粉的比较

Duodenal ulcer in South Africa: home-pounded versus milled maize.

作者信息

Tovey Frank I, Hobsley Michael, Segal Isidor, Jayaraj A Paul

机构信息

Department of Surgery, University College London, London, UK.

出版信息

J Gastroenterol Hepatol. 2005 Jul;20(7):1008-11. doi: 10.1111/j.1440-1746.2005.03852.x.

DOI:10.1111/j.1440-1746.2005.03852.x

PMID:15955207

Abstract

BACKGROUND

In South Africa there is suggestive evidence that home-pounded maize protects against duodenal ulceration. Therefore the purpose of the present paper was to test, in an animal model, whether oil from home-pounded maize gives protection against ulceration and whether this effect is present in commercially prepared maize oil.

METHODS

Gastric ulceration was induced in rats with topical ethanol 1 h after giving oil prepared either from fresh-pounded or from commercially treated maize. The lengths of the linear ulcers produced were measured with a planimeter and summed in each rat. Control observations were made using arachis oil (which is known not to be ulceroprotective) and horse gram lipid (which is known to be strongly ulceroprotective). Statistical comparisons were performed mainly with the Mann-Whitney U-test, but also with reference to the normal distribution. Thin-layer chromatography (TLC) was performed on the oil from fresh maize, and the fractions similarly investigated for ulceroprotective activity.

RESULTS

Fresh maize oil was strongly ulceroprotective (P = 0.0039), commercial maize oil was not (P = 0.2864). The active ingredient in the fresh maize oil was located in the fraction near the solvent front.

CONCLUSION

These findings support the hypothesis that home-pounded maize protects against duodenal ulceration.

摘要

背景

在南非，有迹象表明，自家捣磨的玉米可预防十二指肠溃疡。因此，本文旨在通过动物模型测试，自家捣磨玉米的油是否具有预防溃疡的作用，以及这种作用在市售玉米油中是否存在。

方法

给大鼠分别喂食新鲜捣磨玉米或市售处理玉米制成的油1小时后，用局部乙醇诱导大鼠胃溃疡。用求积仪测量每条线性溃疡的长度，并将每只大鼠的溃疡长度相加。使用花生油（已知无溃疡保护作用）和豆科山黧豆脂质（已知有很强的溃疡保护作用）进行对照观察。主要采用曼-惠特尼U检验进行统计比较，同时也参考正态分布。对新鲜玉米的油进行薄层色谱分析（TLC），并对各馏分进行类似的溃疡保护活性研究。