World J Gastroenterol. 2011 Aug 21;17(31):3565-6. doi: 10.3748/wjg.v17.i31.3565.
This paper pays a tribute to Dr. Frank I Tovey on his 90th birthday which happens on September 1, 2011, and briefly describes the major findings in his research career and contributions as follows. The geographical prevalence of duodenal ulceration is related to staple diets. Unrefined wheat and maize, soya, certain pulses and millets are associated with a low prevalence while refined wheat, maize and rice, yams, cassava and green banana with a high prevalence. Predominant foodstuffs from low prevalence areas are ulceroprotective in rat peptic ulcer models. The protective activity lies in the lipid fraction present in these foodstuffs. The lipid fraction also promotes ulcer healing, is active both orally and intramuscularly and is ulceroprotective against non-steroidal anti-inflammatory drugs (NSAIDs). The phospholipids and phytosterols present in the lipid have been identified to be responsible for this protective activity. The combination of phospholipids and phytosterols may be of value in the prevention and treatment of duodenal ulceration and protection against the ulcerogenic effect of NSAIDs.
值此 2011 年 9 月 1 日 Frank I Tovey 博士 90 寿辰之际，本文对他的工作致以崇高敬意。下文简要介绍他的主要研究发现和贡献如下。十二指肠溃疡的地域流行情况与主食有关。未精制的小麦和玉米、大豆、某些豆类和小米与低流行率相关，而精制的小麦、玉米和大米、山药、木薯和绿香蕉则与高流行率相关。低流行地区的主要食物在大鼠消化性溃疡模型中具有溃疡保护作用。这种保护活性存在于这些食物的脂质部分中。该脂质部分还促进溃疡愈合，具有口服和肌肉内活性，并且对非甾体抗炎药（NSAIDs）具有溃疡保护作用。已确定脂质中存在的磷脂和植物固醇负责这种保护活性。磷脂和植物固醇的组合可能对十二指肠溃疡的预防和治疗以及对 NSAIDs 的溃疡形成作用具有保护作用。
