Wan Li, Crawford Helen J, Boutros Nash
Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, 24061, USA.
Int J Psychophysiol. 2006 Apr;60(1):1-9. doi: 10.1016/j.ijpsycho.2005.03.024. Epub 2005 Jun 13.
Sensory gating deficits are seen in individuals with schizophrenia and schizotypal disorders, yet smoking influence, regional or lateral difference effects are rarely assessed. We examined sensory gating in smokers and non-smokers within university-level high and low schizotypal personality (HiS and LoS) groups using [Raine, A., 1991. The Schizotypal Personality Questionnaire (SPQ): A measure of schizotypal personality based on DSM-III-R criteria. Schizophr. Bull. 17, 555-564] Schizotypal Personality Questionnaire. Among 39 (18 men; 19 smokers) right-handed undergraduates, a paired-tone paradigm (40 pairs; 10 s ISI; 70 dB, 1000 Hz) was presented in two conditions (smokers while abstaining and after smoking). Sensory gating [S2(P50-N40)/S1(P50-N40)] was assessed at frontal, fronto-central, central, centro-parietal, and parietal midline and lateralized sites. Sensory gating was better at (1) midline than left/right hemispheric sites, and (2) fronto-central and central midline sites. At fronto-central/central lateral sites, (1) among non-smokers, better sensory gating occurred in LoS than HiS, (2) among smokers, better sensory gating occurred in HiS than LoS, and (3) among LoSs, smokers showed less sensory gating than non-smokers. No acute smoking effects emerged. Unlike schizophrenia studies, smoking did not impact sensory gating. Differences among smokers and non-smokers in LoS and HiS groups reinforce need to evaluate both smoking and schizotypal characteristics, as well as midline and lateral sites in anterior to posterior regions, in sensory gating studies.
感觉门控缺陷在精神分裂症和分裂型障碍患者中可见，但吸烟影响、区域或侧别差异效应很少被评估。我们使用[雷恩，A.，1991年。分裂型人格问卷（SPQ）：基于DSM-III-R标准的分裂型人格测量工具。《精神分裂症通报》17，555 - 564]分裂型人格问卷，对大学水平的高、低分裂型人格（HiS和LoS）组中的吸烟者和非吸烟者的感觉门控进行了检查。在39名（18名男性；19名吸烟者）右利手本科生中，在两种条件下（吸烟者戒烟时和吸烟后）呈现双音范式（40对；10秒刺激间隔；70分贝，1000赫兹）。在额叶、额中央、中央、中央顶叶和顶叶中线及侧别部位评估感觉门控[S2（P50 - N40）/S1（P50 - N40）]。感觉门控在（1）中线部位比左/右半球部位更好，以及（2）额中央和中央中线部位更好。在额中央/中央外侧部位，（1）在非吸烟者中，LoS组的感觉门控比HiS组更好，（2）在吸烟者中HiS组的感觉门控比LoS组更好，以及（3）在LoS组中，吸烟者的感觉门控比非吸烟者更少。未出现急性吸烟效应。与精神分裂症研究不同，吸烟并未影响感觉门控。LoS组和HiS组中吸烟者与非吸烟者之间的差异强化了在感觉门控研究中评估吸烟和分裂型特征以及前后区域中线和侧别部位的必要性。
