• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Multiple facets of maxi-k+ channels: the heme connection.

作者信息

López-Barneo José, Castellano Antonio

机构信息

Laboratorio de Investigaciones Biomédicas, Hospital Universiteario Virgen del Rocio, Universidad de Sevilla, Seville, Spain.

出版信息

J Gen Physiol. 2005 Jul;126(1):1-5. doi: 10.1085/jgp.200509338. Epub 2005 Jun 13.

DOI:10.1085/jgp.200509338
PMID:15955878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2266619/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c869/2266619/335ac9a2f2e0/200509338f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c869/2266619/7a521669de6d/200509338f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c869/2266619/335ac9a2f2e0/200509338f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c869/2266619/7a521669de6d/200509338f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c869/2266619/335ac9a2f2e0/200509338f2.jpg

相似文献

1
Multiple facets of maxi-k+ channels: the heme connection.大电导钙激活钾通道（Maxi-K+通道）的多个方面：血红素连接
J Gen Physiol. 2005 Jul;126(1):1-5. doi: 10.1085/jgp.200509338. Epub 2005 Jun 13.
2
Heme regulates allosteric activation of the Slo1 BK channel.血红素调节Slo1 BK通道的变构激活。
J Gen Physiol. 2005 Jul;126(1):7-21. doi: 10.1085/jgp.200509262. Epub 2005 Jun 13.
3
Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels.无配体MthK门控环的晶体结构：对钾离子通道配体门控机制的深入了解
Cell. 2006 Sep 22;126(6):1161-73. doi: 10.1016/j.cell.2006.08.029.
4
Delayed expression of large conductance K+ channels reshaping agonist-induced currents in mouse pancreatic acinar cells.大电导钾通道的延迟表达重塑小鼠胰腺腺泡细胞中激动剂诱导的电流。
J Physiol. 2005 Mar 1;563(Pt 2):379-91. doi: 10.1113/jphysiol.2004.077834. Epub 2004 Dec 20.
5
BK channel news: full coverage on the calcium bowl.BK通道新闻：关于钙池的全面报道。
J Gen Physiol. 2004 May;123(5):471-3. doi: 10.1085/jgp.200409069.
6
Gating mechanism of BK (Slo1) channels: so near, yet so far.大电导钙激活钾通道（Slo1）的门控机制：近在咫尺，却又远在天涯。
J Gen Physiol. 2003 Feb;121(2):81-96. doi: 10.1085/jgp.20028721.
7
[Calculation of local Hurst exponents in the Ca(2+)-activated K(+)-channel dwell time].
Biofizika. 2004 Nov-Dec;49(6):1075-83.
8
Tuning the mechanosensitivity of a BK channel by changing the linker length.通过改变连接子长度来调节大电导钙激活钾通道的机械敏感性。
Cell Res. 2008 Aug;18(8):871-8. doi: 10.1038/cr.2008.88.
9
Allosteric modulation of ion channels: the case of maxi-K.离子通道的变构调节：大电导钙激活钾通道的情况
Sci STKE. 2004 Mar 30;2004(227):pe16. doi: 10.1126/stke.2272004pe16.
10
Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.4-（5-氯-2-羟基苯基）-3-（2-羟乙基）-6-（三氟甲基）喹啉-2（1H）-酮（BMS-223131），一种新型的大电导钙激活钾通道（maxi-K通道）开放剂，对正常及应激加重的结肠动力和内脏痛觉的影响
J Pharmacol Exp Ther. 2005 May;313(2):840-7. doi: 10.1124/jpet.104.079285. Epub 2005 Feb 8.

引用本文的文献

1
Acute oxygen sensing in heme oxygenase-2 null mice.血红素加氧酶-2基因敲除小鼠的急性氧感知
J Gen Physiol. 2006 Oct;128(4):405-11. doi: 10.1085/jgp.200609591. Epub 2006 Sep 11.

本文引用的文献

1
Heme regulates allosteric activation of the Slo1 BK channel.血红素调节Slo1 BK通道的变构激活。
J Gen Physiol. 2005 Jul;126(1):7-21. doi: 10.1085/jgp.200509262. Epub 2005 Jun 13.
2
Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.BK通道激活的二价阳离子敏感性支持三个不同结合位点的存在。
J Gen Physiol. 2005 Mar;125(3):273-86. doi: 10.1085/jgp.200409239.
3
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel.血红素加氧酶-2是一种钙敏钾通道的氧传感器。
Science. 2004 Dec 17;306(5704):2093-7. doi: 10.1126/science.1105010. Epub 2004 Nov 4.
4
Linker-gating ring complex as passive spring and Ca(2+)-dependent machine for a voltage- and Ca(2+)-activated potassium channel.连接子门控环复合物作为电压和钙激活钾通道的被动弹簧及钙依赖机器
Neuron. 2004 Jun 10;42(5):745-56. doi: 10.1016/j.neuron.2004.05.001.
5
Hematoma removal, heme, and heme oxygenase following hemorrhagic stroke.出血性中风后的血肿清除、血红素与血红素加氧酶
Ann N Y Acad Sci. 2004 Mar;1012:237-51. doi: 10.1196/annals.1306.020.
6
Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing.活性氧通过改变半胱氨酸介导的钙传感来损害Slo1 BK通道功能。
Nat Struct Mol Biol. 2004 Feb;11(2):171-8. doi: 10.1038/nsmb725. Epub 2004 Jan 25.
7
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels.血红素可以结合并抑制哺乳动物的钙依赖性Slo1 BK通道。
Nature. 2003 Oct 2;425(6957):531-5. doi: 10.1038/nature02003.
8
Gating mechanism of BK (Slo1) channels: so near, yet so far.大电导钙激活钾通道（Slo1）的门控机制：近在咫尺，却又远在天涯。
J Gen Physiol. 2003 Feb;121(2):81-96. doi: 10.1085/jgp.20028721.
9
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels.大电导（BK）钾通道中电压传感器激活、Ca2+结合与通道开放之间的偶联。
J Gen Physiol. 2002 Sep;120(3):267-305. doi: 10.1085/jgp.20028605.
10
Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease.抗氧化血红素加氧酶活性降低：对局部缺血和阿尔茨海默病的影响。
Free Radic Biol Med. 2002 Jun 15;32(12):1276-82. doi: 10.1016/s0891-5849(02)00805-5.