普拉德-威利综合征患者胃底和胃体中表达胃饥饿素的细胞密度增加。

Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome.

作者信息

Choe Yon Ho, Song Sang Yong, Paik Kyung-Hoon, Oh Yoo Joung, Chu Su-Hyun, Yeo Sung Hee, Kwon Eun Kyung, Kim Eun Mee, Rha Mee Yong, Jin Dong-Kyu

机构信息

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Il-Won Dong, Gang-Nam Gu, Seoul, 135-710, Korea.

出版信息

J Clin Endocrinol Metab. 2005 Sep;90(9):5441-5. doi: 10.1210/jc.2004-1935. Epub 2005 Jun 14.

DOI:10.1210/jc.2004-1935

PMID:15956087

Abstract

CONTEXT

The levels of ghrelin, an orexigenic hormone secreted by oxyntic cells in the digestive tract, are elevated in Prader-Willi syndrome (PWS) and GH deficiency (GHD) patients. In this study, we hypothesized that the hyperghrelinemia observed in PWS is related to IGF-I or GH/IGF axis deficiency.

DESIGN

We investigated the densities of ghrelin-expressing cells (GECs), the amounts of ghrelin in gastric tissues, and ghrelin levels in plasma in 16 PWS patients and compared these results with those of 13 GHD patients and comparison groups (19 normal lean and 10 normal obese subjects).

RESULTS

In the gastric body and fundus, 2- to 3-fold increases in the numbers of GECs (P < 0.001) and in the amounts of ghrelin (P < 0.018) were noted in PWS patients vs. comparison groups, whereas GEC numbers in GHD patients were similar to those of the comparison group despite elevated fasting plasma ghrelin levels. In addition, IGF-I sd scores in PWS were not found to be correlated with GEC densities, the amounts of ghrelin expressed in gastric tissues, or plasma ghrelin levels.

CONCLUSIONS

Our results suggest that IGF-I or GH/IGF axis deficiency appears to be unrelated to observed GEC increases in the stomach of patients with PWS.

摘要

背景

胃泌素释放肽是一种由消化道壁细胞分泌的促食欲激素，普拉德-威利综合征（PWS）和生长激素缺乏症（GHD）患者的胃泌素释放肽水平升高。在本研究中，我们假设PWS患者中观察到的高胃泌素血症与胰岛素样生长因子-I（IGF-I）或生长激素/胰岛素样生长因子轴缺乏有关。

设计

我们调查了16例PWS患者胃泌素释放肽表达细胞（GECs）的密度、胃组织中胃泌素释放肽的含量以及血浆中胃泌素释放肽水平，并将这些结果与13例GHD患者及对照组（19例正常体重者和10例正常肥胖者）的结果进行比较。

结果

与对照组相比，PWS患者胃体和胃底的GEC数量增加了2至3倍（P<0.001），胃泌素释放肽含量增加（P<0.018），而GHD患者的GEC数量与对照组相似，尽管空腹血浆胃泌素释放肽水平升高。此外，未发现PWS患者的IGF-I标准差分数与GEC密度、胃组织中表达的胃泌素释放肽含量或血浆胃泌素释放肽水平相关。