伴有血液及骨髓中人类细小病毒B19基因组检测的儿童经典型暂时性红细胞生成减少症。

Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow.

作者信息

Prassouli Alexia, Papadakis Vassilios, Tsakris Athanasios, Stefanaki Kalliopi, Garoufi Anastasia, Haidas Stavros, Dracou Christina

机构信息

Second Department of Pediatrics, Panagiotis and Aglaia Kyriakou Children's Hospital, Athens, Greece.

出版信息

J Pediatr Hematol Oncol. 2005 Jun;27(6):333-6. doi: 10.1097/01.mph.0000169249.72858.8c.

DOI:10.1097/01.mph.0000169249.72858.8c

PMID:15956889

Abstract

The etiology of transient erythroblastopenia of childhood (TEC) remains unknown, although an association with viral infections has been proposed. The authors describe a 3.5-year-old girl with classic TEC concomitantly with human parvovirus B19 (HPV) infection. The infection was evident by detection of HPV genome in the blood and the bone marrow by polymerase chain reaction. Viral genome was no longer detected when the TEC resolved clinically. The patient was immunocompetent and the anemia has not recurred. To the authors' knowledge, this is one of the few documented cases of classic TEC attributable to HPV infection.

摘要

儿童一过性红细胞生成减少症（TEC）的病因尚不清楚，尽管有人提出它与病毒感染有关。作者描述了一名3.5岁的患有典型TEC的女孩，同时感染了人细小病毒B19（HPV）。通过聚合酶链反应在血液和骨髓中检测到HPV基因组，证明了感染的存在。当TEC临床症状缓解时，病毒基因组不再被检测到。该患者免疫功能正常，贫血未复发。据作者所知，这是少数几例有记录的由HPV感染引起的典型TEC病例之一。