Penchansky L, Jordan J A
Department of Pathology, University of Pittsburgh, Pennsylvania, USA.
Am J Clin Pathol. 1997 Aug;108(2):127-32. doi: 10.1093/ajcp/108.2.127.
Transient erythroblastopenia of childhood (TEC) is a disorder of young children ages 3 months to 4 years that is characterized by anemia associated with reticulOcytopenia and decreased red blood cell precursors in the bone marrow aspirate (BMA). A viral cause has been suspected for TEC. Bone marrow aspirate-derived DNA from 14 children with anemia or another hematologic disorder, including two children with TEC, were analyzed by polymerase chain reaction for human herpesvirus type 6 (HHV-6) DNA and human parvovirus B19 DNA. Testing revealed an HHV-6 variant B DNA in both children with TEC but not in the children who did not have TEC. The BMAs from these two children contained large pronormoblasts and an extensive lymphoid infiltrate. We proposed that HHV-6 may be a causative agent of TEC in immunocompetent children. This hypothesis is based on the demonstrated ability of HHV-6 to suppress the formation of burst-forming units-erythroid (BFU-E) and granulocyte macrophage-colony-forming units (GM-CFU) in vitro, and in vivo in HHV-6-infected patients who undergo bone marrow transplantation.
儿童暂时性红细胞生成减少症（TEC）是一种发生于3个月至4岁幼儿的疾病，其特征为贫血，伴有网织红细胞减少以及骨髓穿刺液（BMA）中红细胞前体细胞减少。人们怀疑TEC由病毒引起。采用聚合酶链反应对14名患有贫血或其他血液系统疾病的儿童（包括两名患有TEC的儿童）的骨髓穿刺液来源的DNA进行了人类疱疹病毒6型（HHV-6）DNA和人细小病毒B19 DNA分析。检测发现，两名患有TEC的儿童均存在HHV-6 B变异体DNA，而未患TEC的儿童则未检测到。这两名儿童的骨髓穿刺液含有大量早幼红细胞和广泛的淋巴细胞浸润。我们提出，HHV-6可能是免疫功能正常儿童TEC的致病因子。这一假设基于以下事实：HHV-6在体外以及在接受骨髓移植的HHV-6感染患者体内均具有抑制红系爆式集落形成单位（BFU-E）和粒细胞巨噬细胞集落形成单位（GM-CFU）形成的能力。
