Perissi Valentina, Rosenfeld Michael G
Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Nat Rev Mol Cell Biol. 2005 Jul;6(7):542-54. doi: 10.1038/nrm1680.
Nuclear receptors regulate many biologically important processes in development and homeostasis by their bimodal function as repressors and activators of gene transcription. A finely tuned modulation of the transcriptional activities of nuclear receptors is crucial for determining highly specific and diversified programmes of gene expression. Recent studies have provided insights into the molecular mechanisms that are required to switch between repression and activation functions, the combinatorial roles of the multiple cofactor complexes that are required for mediating transcriptional regulation, and the central question of how several different signalling pathways can be integrated at the nuclear level to achieve specific profiles of gene expression.
核受体通过其作为基因转录抑制因子和激活因子的双重功能，调节发育和体内平衡中许多生物学上重要的过程。对核受体转录活性进行精细调节对于确定高度特异性和多样化的基因表达程序至关重要。最近的研究深入探讨了在抑制和激活功能之间切换所需的分子机制、介导转录调控所需的多种辅因子复合物的组合作用，以及几个不同信号通路如何在核水平整合以实现特定基因表达谱这一核心问题。
