Ogle Brenda M, Cascalho Marilia, Platt Jeffrey L
Transplantation Biology and the Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Nat Rev Mol Cell Biol. 2005 Jul;6(7):567-75. doi: 10.1038/nrm1678.
Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins. The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.
直到最近，细胞仍被认为是组织中不可或缺的离散组成部分，其状态由细胞分化决定。然而，在某些情况下，干细胞或其后代可与其他类型的细胞融合，混合不同（异型）来源的细胞质甚至遗传物质。异型细胞的融合对于发育、组织修复和疾病发病机制可能至关重要。
