Yang Lei, Melot Romain, Neuburger Markus, Baudoin Olivier
University of Basel , Department of Chemistry , St. Johanns-Ring 19 , CH-4056 Basel , Switzerland . Email:
Chem Sci. 2017 Feb 1;8(2):1344-1349. doi: 10.1039/c6sc04006c. Epub 2016 Oct 11.
The first efficient palladium(0)-catalyzed enantioselective C(sp)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.
报道了首例使用催化手性碱和非手性膦配体的高效钯(0)催化对映选择性C(sp)-H活化反应。发现对联萘酚衍生的磷酸预催化剂和反应条件进行微调对于含有三取代和四取代立体中心的多种吲哚啉产物实现高对映选择性至关重要。
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