对重组促红细胞生成素和促红细胞生成素-β中所含聚山梨酯的超敏反应。
Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin.
作者信息
Steele Richard H, Limaye Sandhya, Cleland Bruce, Chow Josephine, Suranyi Michael G
机构信息
Department of Immunology, Liverpool Hospital, Liverpool BC, New South Wales, Australia.
出版信息
Nephrology (Carlton). 2005 Jun;10(3):317-20. doi: 10.1111/j.1440-1797.2005.00389.x.
The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.
以下病例报告涉及两名对红细胞生长激素——达贝泊汀和促红细胞生成素产生过敏反应的患者。随后的皮肤试验和临床病程表明，这些反应的原因是辅料聚山梨酯80。这一发现可能对近期纯红细胞再生障碍性贫血发病率的上升具有启示意义。
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