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本文引用的文献

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Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.线虫 CAENORHABDITIS ELEGANS 的不分离突变体。
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Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.肌醇1,4,5-三磷酸信号传导调节秀丽隐杆线虫中肌上皮鞘细胞的节律性收缩活动。
Mol Biol Cell. 2004 Aug;15(8):3938-49. doi: 10.1091/mbc.e04-03-0198. Epub 2004 Jun 11.
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Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.秀丽隐杆线虫的Gαq通过一条不依赖磷脂酶Cβ（PLCβ）且依赖血清素的信号通路调节产卵行为，并且可能在神经系统和肌肉中都发挥作用。
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Inositol 1,4,5-trisphosphate receptors modulate Ca2+ sparks and Ca2+ store content in vas deferens myocytes.肌醇1,4,5 -三磷酸受体调节输精管肌细胞中的Ca2+火花和Ca2+储存量。
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6
Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis.秀丽隐杆线虫中肌醇1,4,5 -三磷酸信号通路的调控性破坏揭示了其在进食和胚胎发育中的新功能。
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Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating.不同肌肉行为的调节在交配过程中控制着秀丽隐杆线虫雄性的交配刺。
Cell. 2001 Dec 14;107(6):777-88. doi: 10.1016/s0092-8674(01)00600-6.
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The versatility and universality of calcium signalling.钙信号传导的多功能性与普遍性
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9
Analyses of reproductive interactions that occur after heterospecific matings within the genus Caenorhabditis.对秀丽隐杆线虫属内异种交配后发生的生殖相互作用的分析。
Dev Biol. 2001 Apr 1;232(1):105-14. doi: 10.1006/dbio.2000.0136.
10
Dissection of the promoter region of the inositol 1,4,5-trisphosphate receptor gene, itr-1, in C. elegans: a molecular basis for cell-specific expression of IP3R isoforms.秀丽隐杆线虫中肌醇1,4,5-三磷酸受体基因itr-1启动子区域的剖析：IP3R亚型细胞特异性表达的分子基础。
J Mol Biol. 2001 Feb 16;306(2):145-57. doi: 10.1006/jmbi.2000.4388.

肌醇1,4,5-三磷酸信号传导调节秀丽隐杆线虫雄性的交配行为。

Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males.

作者信息

Gower Nicholas J D, Walker Denise S, Baylis Howard A

机构信息

Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom.

出版信息

Mol Biol Cell. 2005 Sep;16(9):3978-86. doi: 10.1091/mbc.e05-02-0096. Epub 2005 Jun 15.

DOI:10.1091/mbc.e05-02-0096
PMID:15958491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196312/
Abstract

Complex behavior requires the coordinated action of the nervous system and nonneuronal targets. Male mating in Caenorhabditis elegans consists of a series of defined behavioral steps that lead to the physiological outcomes required for successful impregnation. We demonstrate that signaling mediated by inositol 1,4,5-trisphosphate (IP(3)) is required at several points during mating. Disruption of IP(3) receptor (itr-1) function results in dramatic loss of male fertility, due to defects in turning behavior (during vulva location), spicule insertion and sperm transfer. To elucidate the signaling pathways responsible, we knocked down the six C. elegans genes encoding phospholipase C (PLC) family members. egl-8, which encodes PLC-beta, functions in spicule insertion and sperm transfer. itr-1 and egl-8 are widely expressed in the male reproductive system. An itr-1 gain-of-function mutation rescues infertility caused by egl-8 RNA interference, indicating that egl-8 and itr-1 function together as central components of the signaling events controlling sperm transfer.

摘要

复杂行为需要神经系统和非神经元靶点的协同作用。秀丽隐杆线虫中的雄性交配由一系列明确的行为步骤组成，这些步骤会导致成功受孕所需的生理结果。我们证明，在交配过程中的几个阶段都需要由肌醇-1,4,5-三磷酸（IP(3)）介导的信号传导。IP(3)受体（itr-1）功能的破坏会导致雄性生育能力急剧丧失，这是由于转向行为（在外阴定位期间）、交合刺插入和精子转移方面的缺陷所致。为了阐明相关的信号通路，我们敲低了秀丽隐杆线虫中编码磷脂酶C（PLC）家族成员的六个基因。编码PLC-β的egl-8在交合刺插入和精子转移中发挥作用。itr-1和egl-8在雄性生殖系统中广泛表达。itr-1的功能获得性突变可挽救由egl-8 RNA干扰引起的不育，这表明egl-8和itr-1作为控制精子转移的信号事件的核心成分共同发挥作用。