Qiu Yong, Zhu Feng
Spinal Service, Gulou Hospital, Nanjing University Medical School, Nanjing 210008, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Apr;27(2):148-52.
To investigate the morphology of the growth plates in anterior and posterior spinal column in adolescent idiopathic scoliosis (AIS) and congenital scoliosis (CS) respectively.
Seventeen AIS patients (mean age 13.6 years, ranged 10 to 17 years) were recruited in this study and 10 patients with CS (mean age 9.3 years, ranged 6 to 12 years) were selected as control group. Growth plates were harvested during anterior and posterior surgery and then were paraffin embedded, sectioned at the thickness of 6 microm, and stained with Heametoxylin and Eosin. Quantitative histomorphometric analysis was made to measure the area and height of proliferative and hypertrophic zones by image analysis system.
In AIS, the hypertrophic and proliferative zones were significantly larger and/or higher in anterior column than those in posterior column (P < 0.05). The sizes of different subtype zones were similar in anterior and posterior columns in CS.
The histological difference between anterior and posterior spinal column may exist in patients with AIS. The overgrowth of the anterior spinal column may predispose to lordotic instability and development of spine deformity.
分别研究青少年特发性脊柱侧凸（AIS）和先天性脊柱侧凸（CS）患者脊柱前柱和后柱生长板的形态。
本研究招募了17例AIS患者（平均年龄13.6岁，年龄范围10至17岁），并选取10例CS患者（平均年龄9.3岁，年龄范围6至12岁）作为对照组。在前后路手术中获取生长板，然后进行石蜡包埋，切成6微米厚的切片，并用苏木精和伊红染色。通过图像分析系统进行定量组织形态计量分析，以测量增殖区和肥大区的面积和高度。
在AIS患者中，前柱的肥大区和增殖区明显大于和/或高于后柱（P < 0.05）。CS患者前后柱不同亚型区域的大小相似。
AIS患者脊柱前后柱之间可能存在组织学差异。脊柱前柱过度生长可能易导致脊柱前凸不稳定和脊柱畸形的发展。
