Herve P, Picard N, Le Roy Ladurie M, Silbert D, Cerrina J, Le Roy Ladurie F, Chapelier A, Dartevelle P, Simonneau G, Parquin F
Laboratories d'Explorations Fonctionnelles Respiratories, Hôpital Marie-Lannelongue, Paris, France.
Am Rev Respir Dis. 1992 Jun;145(6):1503-5. doi: 10.1164/ajrccm/145.6.1503.
To investigate whether survivors of heart/lung and double-lung transplantations have normal or increased nonspecific bronchial responsiveness, nine heart/lung and four double-lung transplant recipients with normal lung histology underwent methacholine challenge and voluntary isocapnic dry air hyperventilation (VIH) in a randomized order at a mean time of 14.8 +/- 12.1 months after surgery. Transplant recipients were compared with 10 normal subjects and 11 patients with mild asthma. Asthmatic patients had a mean provocative concentration of methacholine inducing a 20% fall (PC20) in FEV1 of 3.4 +/- 3.6 mg/ml (SD). Seventy seven percent of the transplant recipients and 70% of the normal subjects had PC20 superior to 32 mg/ml. The percentage fall from baseline FEV1 after VIH was 12.6 +/- 10.4% in asthmatic patients as compared with 1.9 +/- 2.9% in transplant recipients (p = 0.002) and 0.45 +/- 1.2% in normal subjects (p = 0.001). The decrease in FEV1 after VIH was similar in transplant recipients and normal subjects (p = 0.14). These results show that heart/lung or double-lung transplant recipients with normal lung histology have a normal response to nonspecific bronchial stimulation.
为了研究心肺联合移植和双肺移植的幸存者是否具有正常或增加的非特异性支气管反应性，对9名肺组织学正常的心肺联合移植受者和4名双肺移植受者，在术后平均14.8±12.1个月时，按照随机顺序进行了乙酰甲胆碱激发试验和自主等碳酸干空气过度通气（VIH）。将移植受者与10名正常受试者和11名轻度哮喘患者进行比较。哮喘患者乙酰甲胆碱诱导第一秒用力呼气容积（FEV1）下降20%的激发浓度（PC20）平均为3.4±3.6mg/ml（标准差）。77%的移植受者和70%的正常受试者的PC20高于32mg/ml。VIH后哮喘患者FEV1较基线下降的百分比为12.6±10.4%，而移植受者为1.9±2.9%（p = 0.002），正常受试者为0.45±1.2%（p = 0.001）。VIH后移植受者和正常受试者FEV1的下降相似（p = 0.14）。这些结果表明，肺组织学正常的心肺联合移植或双肺移植受者对非特异性支气管刺激具有正常反应。
