Bienzle Ulrich, Eggelte Teunis A, Adjei Lydia A, Dietz Ekkehart, Ehrhardt Stephan, Cramer Jakob P, Otchwemah Rowland N, Mockenhaupt Frank P
Institute of Tropical Medicine, Charité-University Medicine Berlin, Berlin, Germany.
Trop Med Int Health. 2005 Jul;10(7):668-71. doi: 10.1111/j.1365-3156.2005.01444.x.
Haptoglobin (Hp) polymorphisms in sub-Saharan Africa have been associated with an increased risk of severe malaria. However, available data are inconclusive. We examined the role of Hp polymorphisms in susceptibility to Plasmodium falciparum infection and to severe malaria in northern Ghana. Three groups each of 290 age and sex-matched children with severe malaria, children with asymptomatic P. falciparum infection and aparasitaemic healthy controls were studied. Hp typing was based on PCR. In all children, Hp1-1, Hp2-1, and Hp2-2 occurred in 32.4%, 54.1%, and 13.5%, respectively. The prevalence of the Hp genotypes did not differ significantly between groups. However, Hp2 alleles were least common in healthy children (0.379), more frequent in parasitaemic controls (0.402), and most common in severe malaria patients (0.434; = 3.7; P = 0.06). In matched pair analysis, no Hp genotype increased the risk of severe malaria. However, using Hp1-1 as a reference, children with Hp2-2 exhibited a slightly increased risk of severe malaria (odds ratio, 1.6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria.
撒哈拉以南非洲地区的触珠蛋白（Hp）多态性与严重疟疾风险增加有关。然而，现有数据尚无定论。我们研究了加纳北部地区Hp多态性在恶性疟原虫感染易感性及严重疟疾易感性中的作用。研究对象分为三组，每组290名年龄和性别匹配的儿童，分别为患有严重疟疾的儿童、无症状恶性疟原虫感染的儿童以及无寄生虫感染的健康对照儿童。Hp分型基于聚合酶链反应（PCR）。在所有儿童中，Hp1-1、Hp2-1和Hp2-2的出现频率分别为32.4%、54.1%和13.5%。各基因型在三组间的患病率无显著差异。然而，Hp2等位基因在健康儿童中最少见（0.379），在寄生虫血症对照组中更常见（0.402），在严重疟疾患者中最常见（0.434；χ² = 3.7；P = 0.06）。在配对分析中，没有Hp基因型增加严重疟疾的风险。然而，以Hp1-1为参照，Hp2-2型儿童患严重疟疾的风险略有增加（优势比，1.6；P = 0.04）。这些结果表明，Hp多态性对严重疟疾发展的影响可能相当有限。
