Tricon Sabine, Burdge Graham C, Williams Christine M, Calder Philip C, Yaqoob Parveen
Hugh Sinclair Unit of Human Nutrition, School of Food Bioscienes, University of Reading, Whiteknights, UK.
Proc Nutr Soc. 2005 May;64(2):171-82. doi: 10.1079/pns2005418.
Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immune function. Several studies of CLA supplementation in human subjects have now been published, but in contrast to animal studies there has been marked variation between reports on the health-related outcomes. The consensus from seventeen published studies in human subjects is that CLA does not affect body weight or body composition. Some detrimental effects of the trans-10,cis-12 CLA isomer have also been reported in terms of altered blood lipid composition and impaired insulin sensitivity. Finally, CLA has only limited effects on immune functions in man. However, there have been reports of some interesting isomer-specific effects of CLA on the blood lipid profile, but not on immune function. These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution.
共轭亚油酸（CLA）是亚油酸共轭二烯衍生物的位置异构体和几何异构体混合物的统称。由于动物实验报告了CLA具有抗癌、抗动脉粥样硬化、抗糖尿病特性以及对身体组成和免疫功能的调节作用，CLA受到了广泛关注。目前已经发表了几项关于人体补充CLA的研究，但与动物研究不同的是，关于健康相关结果的报告之间存在显著差异。对17项已发表的人体研究的共识是，CLA不会影响体重或身体组成。反式-10，顺式-12 CLA异构体在改变血脂组成和损害胰岛素敏感性方面也有一些有害影响。最后，CLA对人体免疫功能的影响有限。然而，有报告称CLA对血脂谱有一些有趣的异构体特异性作用，但对免疫功能没有影响。这些异构体特异性作用需要进一步研究。在了解更多情况之前，应谨慎考虑在人体中补充CLA。
