Montell Denise J
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.
Cell. 2005 Jun 17;121(6):816-7. doi: 10.1016/j.cell.2005.06.003.
Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo is described. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).
通过基底膜的破坏侵入细胞是发育和癌症转移过程中的关键步骤。在本期《细胞》杂志中，描述了一种在蠕虫中用于阐明体内细胞侵袭潜在分子过程的简单且具有遗传易处理性的细胞检测方法。他们证明转录因子Fos是细胞侵袭所必需的，并鉴定出其三个下游靶基因（编码一种基质金属蛋白酶、血影蛋白和一种类脂肪原钙黏蛋白）。
