Bravata Dawn M, Wells Carolyn K, Gulanski Barbara, Kernan Walter N, Brass Lawrence M, Long Judith, Concato John
Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA.
Stroke. 2005 Jul;36(7):1507-11. doi: 10.1161/01.STR.0000170991.63594.b6. Epub 2005 Jun 16.
In the US, blacks have a higher incidence of stroke and more severe strokes than whites. Our objective was to determine if differences in income, education, and insurance, as well as differences in the prevalence of stroke risk factors, accounted for the association between ethnicity and stroke.
We used data from the Third National Health and Nutrition Survey (NHANES III), a cross-sectional sample of the noninstitutionalized US population (1988-1994), and included blacks and whites aged 40 years or older with a self-reported stroke history. Income was assessed using a ratio of income to US Census Bureau annual poverty threshold.
Among 11 163 participants, 2752 (25%) were black and 619 (6%) had a stroke history (blacks: 160/2752 [6%]; whites: 459/8411 [6%]; P=0.48). Blacks had a higher prevalence of 5 risk factors independently associated with stroke: hypertension, treated diabetes, claudication, higher C-reactive protein, and inactivity; whites had a higher prevalence of 3 risk factors: older age, myocardial infarction, and lower high-density lipoprotein cholesterol. Ethnicity was independently associated with stroke after adjusting for the 8 risk factors (adjusted odds ratio, 1.32; 95% CI, 1.04 to 1.67). Ethnicity was not independently associated with stroke after adjustment for income and income was independently associated with stroke (adjusted odds ratios for: ethnicity, 1.15; 95% CI, 0.88 to 1.49; income, 0.89; 95% CI, 0.82 to 0.95). Adjustment for neither education nor insurance altered the ethnicity-stroke association.
In this study of community-dwelling stroke survivors, ethnic differences exist in the prevalence of stroke risk factors and income may explain the association between ethnicity and stroke.
在美国,黑人中风的发病率高于白人,且中风病情更为严重。我们的目的是确定收入、教育和保险方面的差异,以及中风危险因素患病率的差异,是否能够解释种族与中风之间的关联。
我们使用了第三次全国健康与营养调查(NHANES III)的数据,这是一个非机构化美国人口的横断面样本(1988 - 1994年),纳入了年龄在40岁及以上且有自我报告中风病史的黑人和白人。收入通过收入与美国人口普查局年度贫困阈值的比率来评估。
在11163名参与者中,2752人(25%)为黑人,619人(6%)有中风病史(黑人:160/2752 [6%];白人:459/8411 [6%];P = 0.48)。黑人中与中风独立相关的5种危险因素的患病率更高:高血压、接受治疗的糖尿病、间歇性跛行、较高的C反应蛋白和缺乏运动;白人中3种危险因素的患病率更高:年龄较大、心肌梗死和较低的高密度脂蛋白胆固醇。在对8种危险因素进行调整后,种族与中风独立相关(调整后的优势比为1.32;95%置信区间为1.04至1.67)。在对收入进行调整后,种族与中风不再独立相关,且收入与中风独立相关(调整后的优势比分别为:种族,1.15;95%置信区间为0.88至1.49;收入,0.89;95%置信区间为0.82至0.95)。对教育或保险进行调整均未改变种族与中风之间的关联。
在这项对社区居住的中风幸存者的研究中,中风危险因素的患病率存在种族差异,收入可能解释了种族与中风之间的关联。