Kotsis V T, Stabouli S V, Pitiriga V Ch, Lekakis J P, Nanas I N, Toumanidis S T, Zakopoulos N A
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodestrial University, Athens, Greece.
Transplant Proc. 2005 Jun;37(5):2244-6. doi: 10.1016/j.transproceed.2005.03.087.
The aim of the present study was to evaluate 24 hours blood pressure (BP) and heart rate changes as well as 24-hour circadian BP rhythm of cardiac transplant recipients.
Twenty-five transplant recipients and twenty-five healthy volunteers underwent 24-hour ambulatory BP monitoring. Parameters of 24-hour ambulatory BP monitoring (24-h/daytime/nightime systolic, diastolic BP, pulse pressure, and heart rate) were determined in all patients.
Clinic systolic/diastolic BP, mean 24-h systolic/diastolic BP, mean daytime systolic/diastolic BP, mean nighttime systolic/diastolic BP, and mean 24-h/daytime/nighttime heart rate were significantly higher in transplant recipients than in control group subjects. Standard deviations of 24-h/daytime/nighttime heart rates were significantly lower in transplant recipients. Dippers were 48% of the control and only 12% of the transplantation group.
Cardiac transplant recipients had increased ambulatory BP. They also had increased 24-h/daytime/nighttime heart rate and decreased heart rate variability. Also, diminished nocturnal decrease of BP was found in transplant recipients.
本研究旨在评估心脏移植受者的24小时血压（BP）和心率变化以及24小时血压昼夜节律。
25名移植受者和25名健康志愿者接受了24小时动态血压监测。测定了所有患者24小时动态血压监测的参数（24小时/白天/夜间收缩压、舒张压、脉压和心率）。
移植受者的诊室收缩压/舒张压、24小时平均收缩压/舒张压、白天平均收缩压/舒张压、夜间平均收缩压/舒张压以及24小时/白天/夜间平均心率均显著高于对照组受试者。移植受者24小时/白天/夜间心率的标准差显著更低。杓型血压者在对照组中占48%，在移植组中仅占12%。
心脏移植受者的动态血压升高。他们的24小时/白天/夜间心率也升高，心率变异性降低。此外，还发现移植受者夜间血压下降幅度减小。
