Ricaurte George A, McCann Una D
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Lancet. 2005;365(9477):2137-45. doi: 10.1016/S0140-6736(05)66737-2.
Use of illicit drugs in clubs and large dance parties (so-called raves) is a burgeoning cultural trend. Such recreational drug use is associated with several medical complications, both acute and longlasting. Although few, if any, of the drugs currently used in recreational venues are truly new, their patterns and context of use have changed (a great deal in some instances). For some of these substances, this cultural repackaging of the drug experience has resulted in various medical disorders that have previously gone undocumented. This review aims to help treating physicians recognise and manage complications associated with the use of new drugs in clubs, including methylenedioxymethamfetamine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, flunitrazepam, ketamine, and nitrites. We also alert researchers to specific toxic effects of club-drugs on which more basic information is needed.
在俱乐部和大型舞会（即所谓的锐舞派对）中使用非法药物是一种新兴的文化潮流。这种娱乐性药物使用会引发多种急性和长期的医学并发症。尽管目前在娱乐场所使用的药物几乎没有真正全新的，但它们的使用模式和背景已经发生了变化（在某些情况下变化很大）。对于其中一些物质，这种对药物体验的文化重新包装导致了各种以前未被记录的医学病症。本综述旨在帮助治疗医生识别和处理与在俱乐部使用新型药物相关的并发症，这些药物包括亚甲基二氧甲基苯丙胺、麻黄碱、γ-羟基丁酸、γ-丁内酯、1,4-丁二醇、氟硝西泮、氯胺酮和亚硝酸盐。我们还提醒研究人员注意俱乐部药物的特定毒性作用，对此需要更多的基础信息。
