Williams Anna-Leila, Cotter Anne, Sabina Alyse, Girard Christine, Goodman Jonathan, Katz David L
Yale Prevention Research Center, Derby, CT 06418, USA.
Fam Pract. 2005 Oct;22(5):532-7. doi: 10.1093/fampra/cmi040. Epub 2005 Jun 17.
Major depression is the leading cause of disability worldwide, and among the 10 most frequent indications for using alternative medicine therapies, especially dietary supplements.
To assess the evidence evaluating vitamin B-6 supplementation as treatment for depression.
Medline, Psychinfo, AMED, and Cochrane Controlled Trials Register were searched from database inception through September 2001. All randomized controlled trials, controlled clinical trials, intervention studies, case-control studies, reviews, and case reports examining the evidence behind vitamin B-6 in depression among humans were selected. No limits were placed for demographics or co-morbidities. Only English language papers were abstracted and assessed for trial quality. Two abstractors independently evaluated each study, then reconciled findings. As data were available, between group treatment effect size was noted or, as needed, calculated. When studies reported outcome effects using multiple measures, data were abstracted to permit the greatest possible comparisons among papers.
Ten articles met inclusion criteria; three reviews, one case report, five RCTs, and one intervention study. There was no common outcome measure among all studies, eliminating opportunity for direct comparison of effect sizes. As an alternate means of comparison, effects were plotted as they related to the null hypothesis.
Viewed as a whole, meaningful treatment effect of vitamin B-6 for depression in general was not apparent. However, examination of papers addressing depression in pre-menopausal women only, reveals a consistent message about the value of using vitamin B-6 supplementation. Further study of vitamin B-6 as independent and adjuvant therapy for hormone related depression in women is indicated.
重度抑郁症是全球致残的主要原因，且在使用替代医学疗法（尤其是膳食补充剂）的10种最常见适应症中。
评估评价补充维生素B-6治疗抑郁症的证据。
检索了从数据库建立至2001年9月的Medline、Psychinfo、AMED和Cochrane对照试验注册库。选取了所有检验人类抑郁症中维生素B-6依据的随机对照试验、对照临床试验、干预研究、病例对照研究、综述和病例报告。对人口统计学或合并症未设限制。仅提取英文论文并评估试验质量。两名摘要提取者独立评估每项研究，然后核对结果。如有可用数据，记录组间治疗效应量，或根据需要进行计算。当研究使用多种测量方法报告结局效应时，提取数据以便尽可能在各论文间进行比较。
10篇文章符合纳入标准；3篇综述、1篇病例报告、5项随机对照试验和1项干预研究。所有研究中没有共同的结局测量指标，排除了直接比较效应量的机会。作为一种替代比较方法，将效应与无效假设相关联进行绘制。
总体来看，维生素B-6对抑郁症的有意义治疗效果并不明显。然而，仅对绝经前女性抑郁症相关论文的审查显示，关于使用维生素B-6补充剂的价值有一致的信息。表明需要进一步研究维生素B-6作为女性激素相关抑郁症的独立和辅助疗法。
