Meltzer H M, Norheim G, Løken E B, Holm H
University of Oslo, Institute for Nutrition Research, School of Medicine, Norway.
Br J Nutr. 1992 Mar;67(2):287-94. doi: 10.1079/bjn19920032.
In spite of a rather modest dietary intake of selenium (80 micrograms/10 MJ), Norwegian serum Se levels are among the highest in Europe. As part of an ongoing study of Se bioavailability, effects of different doses of wheat Se were investigated in eighteen healthy, Norwegian women. The participants were given Se-rich bread providing 100, 200 and 300 micrograms Se daily for 6 weeks. About 50% of the Se intake was excreted in the urine by week 6, compared with 67% before the intervention started. Serum Se increased by 20, 37 and 53 micrograms/l respectively, in the three group (P less than 0.001). The blood response and renal clearance results compare well with data obtained from less Se-replete populations, and support the hypothesis that selenomethionine from the diet is incorporated into a non-specific amino acid pool. Our study indicates that the intake of wheat Se is the main determinant of blood Se levels in Norway.
尽管挪威人的硒膳食摄入量相对适中（80微克/10兆焦耳），但其血清硒水平在欧洲却位居前列。作为一项正在进行的硒生物利用度研究的一部分，对18名健康的挪威女性进行了不同剂量小麦硒效果的调查。参与者连续6周每天食用富含硒的面包，分别提供100、200和300微克的硒。到第6周时，约50%的硒摄入量通过尿液排出，而干预开始前这一比例为67%。三组血清硒分别升高了20、37和53微克/升（P<0.001）。血液反应和肾脏清除结果与从硒缺乏程度较低人群获得的数据相当吻合，并支持饮食中的硒代蛋氨酸被纳入非特异性氨基酸池的假说。我们的研究表明，小麦硒的摄入量是挪威血液硒水平的主要决定因素。
