Paul R, Knebel C, van Randenborgh H, Kübler H, Alschibaja M, Günther M, Hartung R
Urologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität, München.
Urologe A. 2005 Sep;44(9):1052, 1054-8. doi: 10.1007/s00120-005-0859-8.
There is controversy regarding tumor control of incidental prostate cancer (PC). We evaluated in a large cohort if we can recommend radical prostatectomy after TURP.
In 52 (4.3%) from a total of 1207 patients undergoing radical prostatectomy the diagnosis had been made by TURP. In a retrospective analysis we evaluated morbidity, histopathological results, and tumor control of pT1a/b tumors.
The number of incidentally detected PC decreased with time. In 5.8% in the TURP group and in 0.5% of the needle biopsy group, there was no residual tumor found (p<0.001). Morbidity was similar +/- TURP with the exception of operation time (206 vs 188 min) and catheter duration (19.3 vs 17.3 days). Postoperative continence was identical. There was no difference in tumor control for local recurrence-free survival and PSA-free survival with and without TURP.
The rate of incidentally detected PC by TURP decreases over time, but in almost all cases we found clinically relevant cancer. TURP is not an adverse prognostic factor and morbidity is similar compared with patients who were diagnosed by needle biopsy. Our data confirm that we should recommend radical prostatectomy to patients who are candidates for further curative therapy.
关于偶发性前列腺癌(PC)的肿瘤控制存在争议。我们在一个大型队列中评估了经尿道前列腺电切术(TURP)后是否可以推荐行根治性前列腺切除术。
在总共1207例行根治性前列腺切除术的患者中,有52例(4.3%)是通过TURP确诊的。在一项回顾性分析中,我们评估了pT1a/b期肿瘤的发病率、组织病理学结果和肿瘤控制情况。
偶发性前列腺癌的检出数量随时间减少。TURP组中有5.8%、穿刺活检组中有0.5%未发现残留肿瘤(p<0.001)。除手术时间(206分钟对188分钟)和导尿管留置时间(19.3天对17.3天)外,TURP与否的发病率相似。术后控尿情况相同。有无TURP在局部无复发生存率和无前列腺特异抗原(PSA)生存率的肿瘤控制方面无差异。
TURP检出偶发性前列腺癌的比例随时间下降,但几乎在所有病例中我们都发现了具有临床意义的癌症。TURP不是不良预后因素,与经穿刺活检确诊的患者相比,发病率相似。我们的数据证实,对于有进一步根治性治疗指征的患者,我们应推荐行根治性前列腺切除术。