Sylvester Karl P, Milligan Peter, Patey Richard A, Rafferty Gerrard F, Greenough Anne
Division of Asthma, Allergy, and Lung Biology, Guy's, King's, and St. Thomas' School of Medicine, King's College, London, UK.
Pediatr Pulmonol. 2005 Aug;40(2):109-12. doi: 10.1002/ppul.20259.
Lung volumes in healthy children differ according to their ethnic origin. We wished to determine if any differences in the lung volumes of Afro-Caribbean (AC) children from those predicted by Caucasian reference values disappeared if the results were related to sitting height or to 90% or 77% of lung volumes predicted for height from Caucasian reference values based on standing height. We took, as our working hypothesis, that it is inappropriate to use Caucasian reference values to interpret data from Afro-Caribbean children, and that ethnic-specific reference values are required. This was a prospective, observational study. Subjects included 80 AC children with a median age of 9 (range, 4.3-17.8) years. Standing and sitting height were measured. Lung volumes were measured by body plethysmography (total lung capacity, TLC(pleth); functional residual capacity, FRC(pleth); and vital capacity, VC(pleth)), helium gas dilution (functional residual capacity, (FRC(He)), spirometry (forced expiratory volume in 1 sec, FEV(1)), and forced vital capacity (FVC). The lung volumes of AC children correlated significantly with standing height, but differed significantly from values predicted from Caucasian reference values based on standing height (P < 0.05). Significant differences remained for TLC(pleth), FRC(pleth), FRC(He), RV(pleth), VC(pleth), FEV(1), and FVC when the results were related to sitting height or 90% or 77% of values predicted from Caucasian reference values based on height (P < 0.05). Lung volumes in Afro-Caribbean children should be compared to ethnic-specific reference values.
健康儿童的肺容积因种族不同而存在差异。我们想确定，如果将非洲加勒比裔（AC）儿童的肺容积结果与坐高相关联，或者与根据白种人基于身高的参考值预测的肺容积的90%或77%相关联，那么与白种人参考值预测结果相比，这些儿童的肺容积差异是否会消失。我们的工作假设是，使用白种人参考值来解释非洲加勒比裔儿童的数据是不合适的，需要特定种族的参考值。这是一项前瞻性观察研究。研究对象包括80名AC儿童，中位年龄为9岁（范围4.3 - 17.8岁）。测量了身高和坐高。通过体容积描记法测量肺容积（肺总量，TLC(pleth)；功能残气量，FRC(pleth)；肺活量，VC(pleth)）、氦气稀释法（功能残气量，FRC(He)）、肺量计测量法（1秒用力呼气量，FEV(1)）和用力肺活量（FVC）。AC儿童的肺容积与身高显著相关，但与基于身高的白种人参考值预测的结果有显著差异（P < 0.05）。当结果与坐高或基于身高的白种人参考值预测值的90%或77%相关联时，TLC(pleth)、FRC(pleth)、FRC(He)、残气量（RV(pleth)）、VC(pleth)、FEV(1)和FVC仍存在显著差异（P < 0.05）。非洲加勒比裔儿童的肺容积应与特定种族的参考值进行比较。
